Chemical tools to define and manipulate interferon-inducible Ubl protease USP18
Chemical tools to define and manipulate interferon-inducible Ubl protease USP18
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Ubiquitin-specific protease 18 (USP18) is a multifunctional cysteine protease primarily responsible for deconjugating the interferon-inducible ubiquitin-like modifier ISG15 from protein substrates. Here, we report the design and synthesis of activity-based probes (ABPs) that incorporate unnatural amino acids into the C-terminal tail of ISG15, enabl...
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Chemical tools to define and manipulate interferon-inducible Ubl protease USP18
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TN_cdi_doaj_primary_oai_doaj_org_article_150b00e079594d35a3975382116fcc85
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_150b00e079594d35a3975382116fcc85
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-025-56336-5
