Circular non-coding RNA ANRIL modulates ribosomal RNA maturation and atherosclerosis in humans
Circular non-coding RNA ANRIL modulates ribosomal RNA maturation and atherosclerosis in humans
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Author / Creator
Holdt, Lesca M. , Stahringer, Anika , Sass, Kristina , Pichler, Garwin , Kulak, Nils A. , Wilfert, Wolfgang , Kohlmaier, Alexander , Herbst, Andreas , Northoff, Bernd H. , Nicolaou, Alexandros , Gäbel, Gabor , Beutner, Frank , Scholz, Markus , Thiery, Joachim , Musunuru, Kiran , Krohn, Knut , Mann, Matthias and Teupser, Daniel
Publisher
London: Nature Publishing Group UK
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English
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Publisher
London: Nature Publishing Group UK
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Contents
Circular RNAs (circRNAs) are broadly expressed in eukaryotic cells, but their molecular mechanism in human disease remains obscure. Here we show that
circular antisense non-coding RNA in the INK4 locus
(
circANRIL
), which is transcribed at a locus of atherosclerotic cardiovascular disease on chromosome 9p21, confers atheroprotection by...
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Full title
Circular non-coding RNA ANRIL modulates ribosomal RNA maturation and atherosclerosis in humans
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TN_cdi_doaj_primary_oai_doaj_org_article_151d6b7d2525435dacde77b53d5d85b1
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_151d6b7d2525435dacde77b53d5d85b1
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms12429
