Mutational cooperativity of RUNX1::RUNX1T1 isoform 9a and oncogenic NRAS in zebrafish myeloid leukae...
Mutational cooperativity of RUNX1::RUNX1T1 isoform 9a and oncogenic NRAS in zebrafish myeloid leukaemia
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Publisher
England: The Company of Biologists Ltd
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Language
English
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Publisher
England: The Company of Biologists Ltd
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RUNX1::RUNX1T1 (R::RT1) acute myeloid leukaemia (AML) remains a clinical challenge, and further research is required to model and understand leukaemogenesis. Previous zebrafish R::RT1 models were hampered by embryonic lethality and low penetrance of the malignant phenotype. Here, we overcome this by developing an adult zebrafish model in which the...
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Full title
Mutational cooperativity of RUNX1::RUNX1T1 isoform 9a and oncogenic NRAS in zebrafish myeloid leukaemia
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TN_cdi_doaj_primary_oai_doaj_org_article_153047675ef2422ea69c6e5dbe53dcc5
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_153047675ef2422ea69c6e5dbe53dcc5
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ISSN
2046-6390
E-ISSN
2046-6390
DOI
10.1242/bio.060523
