Small molecules as potent biphasic modulators of protein liquid-liquid phase separation
Small molecules as potent biphasic modulators of protein liquid-liquid phase separation
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Liquid-liquid phase separation (LLPS) of proteins that leads to formation of membrane-less organelles is critical to many biochemical processes in the cell. However, dysregulated LLPS can also facilitate aberrant phase transitions and lead to protein aggregation and disease. Accordingly, there is great interest in identifying small molecules that m...
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Small molecules as potent biphasic modulators of protein liquid-liquid phase separation
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TN_cdi_doaj_primary_oai_doaj_org_article_1546e39d54c649998d644f397e8e1d40
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_1546e39d54c649998d644f397e8e1d40
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-19211-z
