An IL-10/DEL-1 axis supports granulopoiesis and survival from sepsis in early life
An IL-10/DEL-1 axis supports granulopoiesis and survival from sepsis in early life
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Author / Creator
Vergadi, Eleni , Kolliniati, Ourania , Lapi, Ioanna , Ieronymaki, Eleftheria , Lyroni, Konstantina , Alexaki, Vasileia Ismini , Diamantaki, Eleni , Vaporidi, Katerina , Hatzidaki, Eleftheria , Papadaki, Helen A. , Galanakis, Emmanouil , Hajishengallis, George , Chavakis, Triantafyllos and Tsatsanis, Christos
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
The limited reserves of neutrophils are implicated in the susceptibility to infection in neonates, however the regulation of neutrophil kinetics in infections in early life remains poorly understood. Here we show that the developmental endothelial locus (DEL-1) is elevated in neonates and is critical for survival from neonatal polymicrobial sepsis,...
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Full title
An IL-10/DEL-1 axis supports granulopoiesis and survival from sepsis in early life
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TN_cdi_doaj_primary_oai_doaj_org_article_15720238d9a64fb09d69c2056ef00ca5
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_15720238d9a64fb09d69c2056ef00ca5
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-44178-y
