GFAT1-linked TAB1 glutamylation sustains p38 MAPK activation and promotes lung cancer cell survival...
GFAT1-linked TAB1 glutamylation sustains p38 MAPK activation and promotes lung cancer cell survival under glucose starvation
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Author / Creator
Wei, Shupei , Zhao, Qin , Zheng, Ke , Liu, Peiying , Sha, Nannan , Li, Yingzi , Ma, Chunmin , Li, Jingjie , Zhuo, Lingang , Liu, Guanxin , Liang, Wenhua , Jiang, Yuhui , Chen, Tao and Zhong, Nanshan
Publisher
Singapore: Springer Nature Singapore
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Language
English
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Publisher
Singapore: Springer Nature Singapore
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Reprogrammed cell metabolism is deemed as one of the hallmarks of cancer. Hexosamine biosynthesis pathway (HBP) acts as an “energy sensor” in cells to regulate metabolic fluxes. Glutamine-fructose-6-phosphate amidotransferase 1 (GFAT1), the rate-limiting enzyme of HBP, is broadly found with elevated expression in human cancers though its exact and...
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Full title
GFAT1-linked TAB1 glutamylation sustains p38 MAPK activation and promotes lung cancer cell survival under glucose starvation
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TN_cdi_doaj_primary_oai_doaj_org_article_15cec999f08d43f49df0d86ff27c9fa8
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_15cec999f08d43f49df0d86ff27c9fa8
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ISSN
2056-5968
E-ISSN
2056-5968
DOI
10.1038/s41421-022-00423-0
