Combined fibre atrophy and decreased muscle regeneration capacity driven by mitochondrial DNA altera...
Combined fibre atrophy and decreased muscle regeneration capacity driven by mitochondrial DNA alterations underlie the development of sarcopenia
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Publisher
Heidelberg: John Wiley & Sons, Inc
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Language
English
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Publisher
Heidelberg: John Wiley & Sons, Inc
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Background
Mitochondrial dysfunction caused by mitochondrial (mtDNA) deletions have been associated with skeletal muscle atrophy and myofibre loss. However, whether such defects occurring in myofibres cause sarcopenia is unclear. Also, the contribution of mtDNA alterations in muscle stem cells (MuSCs) to sarcopenia remains to be investigated.
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Full title
Combined fibre atrophy and decreased muscle regeneration capacity driven by mitochondrial DNA alterations underlie the development of sarcopenia
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TN_cdi_doaj_primary_oai_doaj_org_article_15e959a1114e4a8dadd0b7d4b985fc9e
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_15e959a1114e4a8dadd0b7d4b985fc9e
Other Identifiers
ISSN
2190-5991
E-ISSN
2190-6009
DOI
10.1002/jcsm.13026
