Structure of Rap1b bound to talin reveals a pathway for triggering integrin activation
Structure of Rap1b bound to talin reveals a pathway for triggering integrin activation
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Activation of transmembrane receptor integrin by talin is essential for inducing cell adhesion. However, the pathway that recruits talin to the membrane, which critically controls talin’s action, remains elusive. Membrane-anchored mammalian small GTPase Rap1 is known to bind talin-F0 domain but the binding was shown to be weak and thus hardly studi...
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Full title
Structure of Rap1b bound to talin reveals a pathway for triggering integrin activation
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TN_cdi_doaj_primary_oai_doaj_org_article_15ed6742ffb34d9d884d48e64df0be10
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_15ed6742ffb34d9d884d48e64df0be10
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-017-01822-8
