Genome-wide association study implicates novel loci and reveals candidate effector genes for longitu...
Genome-wide association study implicates novel loci and reveals candidate effector genes for longitudinal pediatric bone accrual
About this item
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Author / Creator
Cousminer, Diana L. , Wagley, Yadav , Pippin, James A. , Elhakeem, Ahmed , Way, Gregory P. , Pahl, Matthew C. , McCormack, Shana E. , Chesi, Alessandra , Mitchell, Jonathan A. , Kindler, Joseph M. , Baird, Denis , Hartley, April , Howe, Laura , Kalkwarf, Heidi J. , Lappe, Joan M. , Lu, Sumei , Leonard, Michelle E. , Johnson, Matthew E. , Hakonarson, Hakon , Gilsanz, Vicente , Shepherd, John A. , Oberfield, Sharon E. , Greene, Casey S. , Kelly, Andrea , Lawlor, Deborah A. , Voight, Benjamin F. , Wells, Andrew D. , Zemel, Babette S. , Hankenson, Kurt D. and Grant, Struan F. A.
Publisher
England: BioMed Central Ltd
Journal title
Language
English
Formats
Publication information
Publisher
England: BioMed Central Ltd
Subjects
More information
Scope and Contents
Contents
Bone accrual impacts lifelong skeletal health, but genetic discovery has been primarily limited to cross-sectional study designs and hampered by uncertainty about target effector genes. Here, we capture this dynamic phenotype by modeling longitudinal bone accrual across 11,000 bone scans in a cohort of healthy children and adolescents, followed by...
Alternative Titles
Full title
Genome-wide association study implicates novel loci and reveals candidate effector genes for longitudinal pediatric bone accrual
Authors, Artists and Contributors
Author / Creator
Wagley, Yadav
Pippin, James A.
Elhakeem, Ahmed
Way, Gregory P.
Pahl, Matthew C.
McCormack, Shana E.
Chesi, Alessandra
Mitchell, Jonathan A.
Kindler, Joseph M.
Baird, Denis
Hartley, April
Howe, Laura
Kalkwarf, Heidi J.
Lappe, Joan M.
Lu, Sumei
Leonard, Michelle E.
Johnson, Matthew E.
Hakonarson, Hakon
Gilsanz, Vicente
Shepherd, John A.
Oberfield, Sharon E.
Greene, Casey S.
Kelly, Andrea
Lawlor, Deborah A.
Voight, Benjamin F.
Wells, Andrew D.
Zemel, Babette S.
Hankenson, Kurt D.
Grant, Struan F. A.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_165481b925744dddb170926499acd9cc
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_165481b925744dddb170926499acd9cc
Other Identifiers
ISSN
1474-760X,1474-7596
E-ISSN
1474-760X
DOI
10.1186/s13059-020-02207-9
