Complement regulator CD59 prevents peripheral organ injury in rats made seropositive for neuromyelit...
Complement regulator CD59 prevents peripheral organ injury in rats made seropositive for neuromyelitis optica immunoglobulin G
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England: BioMed Central Ltd
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English
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England: BioMed Central Ltd
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Pathogenesis in aquaporin-4 immunoglobulin G (AQP4-IgG) seropositive neuromyelitis optica spectrum disorders (herein called NMO) involves complement-dependent cytotoxicity initiated by AQP4-IgG binding to astrocyte AQP4. We recently reported that rats lacking complement inhibitor protein CD59 were highly susceptible to development of NMO pathology...
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Complement regulator CD59 prevents peripheral organ injury in rats made seropositive for neuromyelitis optica immunoglobulin G
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TN_cdi_doaj_primary_oai_doaj_org_article_16a8de7bd46e4e6682ec35d9b4ed3824
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_16a8de7bd46e4e6682ec35d9b4ed3824
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ISSN
2051-5960
E-ISSN
2051-5960
DOI
10.1186/s40478-017-0462-4
