Exosomal CD73 from serum of patients with melanoma suppresses lymphocyte functions and is associated...
Exosomal CD73 from serum of patients with melanoma suppresses lymphocyte functions and is associated with therapy resistance to anti-PD-1 agents
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England: BMJ Publishing Group Ltd
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Language
English
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England: BMJ Publishing Group Ltd
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BackgroundCD73 is an ectonucleotidase producing the immunosuppressor mediator adenosine. Elevated levels of circulating CD73 in patients with cancer have been associated with disease progression and poor response to immunotherapy. Immunosuppressive pathways associated with exosomes can affect T-cell function and the therapeutic efficacy of anti-pro...
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Full title
Exosomal CD73 from serum of patients with melanoma suppresses lymphocyte functions and is associated with therapy resistance to anti-PD-1 agents
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TN_cdi_doaj_primary_oai_doaj_org_article_16eb3e6d99c6479e82f78953f59e5073
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_16eb3e6d99c6479e82f78953f59e5073
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ISSN
2051-1426
E-ISSN
2051-1426
DOI
10.1136/jitc-2021-004043
