Macrophage-expressed IFN-β contributes to apoptotic alveolar epithelial cell injury in severe influe...
Macrophage-expressed IFN-β contributes to apoptotic alveolar epithelial cell injury in severe influenza virus pneumonia
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Influenza viruses (IV) cause pneumonia in humans with progression to lung failure and fatal outcome. Dysregulated release of cytokines including type I interferons (IFNs) has been attributed a crucial role in immune-mediated pulmonary injury during severe IV infection. Using ex vivo and in vivo IV infection models, we demonstrate that alveolar macr...
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Full title
Macrophage-expressed IFN-β contributes to apoptotic alveolar epithelial cell injury in severe influenza virus pneumonia
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TN_cdi_doaj_primary_oai_doaj_org_article_16f63be53e5a4d9595813eb57f371aaa
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_16f63be53e5a4d9595813eb57f371aaa
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ISSN
1553-7374,1553-7366
E-ISSN
1553-7374
DOI
10.1371/journal.ppat.1003188
