The type 1 diabetes gene TYK2 regulates β-cell development and its responses to interferon-α
The type 1 diabetes gene TYK2 regulates β-cell development and its responses to interferon-α
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Author / Creator
Chandra, Vikash , Ibrahim, Hazem , Halliez, Clémentine , Prasad, Rashmi B. , Vecchio, Federica , Dwivedi, Om Prakash , Kvist, Jouni , Balboa, Diego , Saarimäki-Vire, Jonna , Montaser, Hossam , Barsby, Tom , Lithovius, Väinö , Artner, Isabella , Gopalakrishnan, Swetha , Groop, Leif , Mallone, Roberto , Eizirik, Decio L. , Otonkoski, Timo , Faculty of Medicine , Medicinska fakulteten , Division of stem cell research , Strategiska forskningsområden (SFO) , Translationell muskelforskning , StemTherapy: National Initiative on Stem Cells for Regenerative Therapy , Department of Laboratory Medicine , Stem Cell Center , Endokrin Celldifferentiering , Institutionen för kliniska vetenskaper, Malmö , Strategic research areas (SRA) , Stamcellscentrum (SCC) , Lunds universitet , Avdelningen för stamcellsforskning , Translational Muscle Research , Profilområden och andra starka forskningsmiljöer , Lund University , EXODIAB: Excellence of Diabetes Research in Sweden , Imaging , Institutionen för laboratoriemedicin , Endocrine Cell Differentiation and Function , Profile areas and other strong research environments , Department of Clinical Sciences, Malmö and Bildbehandlingsplattformen
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Type 1 diabetes (T1D) is an autoimmune disease that results in the destruction of insulin producing pancreatic β-cells. One of the genes associated with T1D is
TYK2
, which encodes a Janus kinase with critical roles in type-Ι interferon (IFN-Ι) mediated intracellular signalling. To study the role of TYK2 in β-cell development and response to...
Alternative Titles
Full title
The type 1 diabetes gene TYK2 regulates β-cell development and its responses to interferon-α
Authors, Artists and Contributors
Author / Creator
Ibrahim, Hazem
Halliez, Clémentine
Prasad, Rashmi B.
Vecchio, Federica
Dwivedi, Om Prakash
Kvist, Jouni
Balboa, Diego
Saarimäki-Vire, Jonna
Montaser, Hossam
Barsby, Tom
Lithovius, Väinö
Artner, Isabella
Gopalakrishnan, Swetha
Groop, Leif
Mallone, Roberto
Eizirik, Decio L.
Otonkoski, Timo
Faculty of Medicine
Medicinska fakulteten
Division of stem cell research
Strategiska forskningsområden (SFO)
Translationell muskelforskning
StemTherapy: National Initiative on Stem Cells for Regenerative Therapy
Department of Laboratory Medicine
Stem Cell Center
Endokrin Celldifferentiering
Institutionen för kliniska vetenskaper, Malmö
Strategic research areas (SRA)
Stamcellscentrum (SCC)
Lunds universitet
Avdelningen för stamcellsforskning
Translational Muscle Research
Profilområden och andra starka forskningsmiljöer
Lund University
EXODIAB: Excellence of Diabetes Research in Sweden
Imaging
Institutionen för laboratoriemedicin
Endocrine Cell Differentiation and Function
Profile areas and other strong research environments
Department of Clinical Sciences, Malmö
Bildbehandlingsplattformen
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Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_1702551117374e95b0db57f6600d8e23
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_1702551117374e95b0db57f6600d8e23
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-34069-z
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