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CDK6 inhibits white to beige fat transition by suppressing RUNX1

CDK6 inhibits white to beige fat transition by suppressing RUNX1

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_17531b3802bd4bc69983bb653e2b2d97

CDK6 inhibits white to beige fat transition by suppressing RUNX1

About this item

Full title

CDK6 inhibits white to beige fat transition by suppressing RUNX1

Publisher

London: Nature Publishing Group UK

Journal title

Nature communications, 2018-03, Vol.9 (1), p.1023-14, Article 1023

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

Whereas white adipose tissue depots contribute to the development of metabolic diseases, brown and beige adipose tissue has beneficial metabolic effects. Here we show that CDK6 regulates beige adipocyte formation. We demonstrate that mice lacking the CDK6 protein or its kinase domain (K43M) exhibit significant increases beige cell formation, enhanc...

Alternative Titles

Full title

CDK6 inhibits white to beige fat transition by suppressing RUNX1

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_17531b3802bd4bc69983bb653e2b2d97

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_17531b3802bd4bc69983bb653e2b2d97

Other Identifiers

ISSN

2041-1723

E-ISSN

2041-1723

DOI

10.1038/s41467-018-03451-1

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