TNFα drives pulmonary arterial hypertension by suppressing the BMP type-II receptor and altering NOT...
TNFα drives pulmonary arterial hypertension by suppressing the BMP type-II receptor and altering NOTCH signalling
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Heterozygous germ-line mutations in the bone morphogenetic protein type-II receptor (BMPR-II) gene underlie heritable pulmonary arterial hypertension (HPAH). Although inflammation promotes PAH, the mechanisms by which inflammation and BMPR-II dysfunction conspire to cause disease remain unknown. Here we identify that tumour necrosis factor-α (TNFα)...
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Full title
TNFα drives pulmonary arterial hypertension by suppressing the BMP type-II receptor and altering NOTCH signalling
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TN_cdi_doaj_primary_oai_doaj_org_article_17874564742043b0848f710d036fb95a
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_17874564742043b0848f710d036fb95a
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms14079
