Dissecting the immunosuppressive tumor microenvironments in Glioblastoma-on-a-Chip for optimized PD-...
Dissecting the immunosuppressive tumor microenvironments in Glioblastoma-on-a-Chip for optimized PD-1 immunotherapy
About this item
Full title
Author / Creator
Cui, Xin , Ma, Chao , Vasudevaraja, Varshini , Serrano, Jonathan , Tong, Jie , Peng, Yansong , Delorenzo, Michael , Shen, Guomiao , Frenster, Joshua , Morales, Renee-Tyler Tan , Qian, Weiyi , Tsirigos, Aristotelis , Chi, Andrew S , Jain, Rajan , Kurz, Sylvia C , Sulman, Erik P , Placantonakis, Dimitris G , Snuderl, Matija and Chen, Weiqiang
Publisher
England: eLife Science Publications, Ltd
Journal title
Language
English
Formats
Publication information
Publisher
England: eLife Science Publications, Ltd
Subjects
More information
Scope and Contents
Contents
Programmed cell death protein-1 (PD-1) checkpoint immunotherapy efficacy remains unpredictable in glioblastoma (GBM) patients due to the genetic heterogeneity and immunosuppressive tumor microenvironments. Here, we report a microfluidics-based, patient-specific ‘GBM-on-a-Chip’ microphysiological system to dissect the heterogeneity of immunosuppress...
Alternative Titles
Full title
Dissecting the immunosuppressive tumor microenvironments in Glioblastoma-on-a-Chip for optimized PD-1 immunotherapy
Authors, Artists and Contributors
Author / Creator
Ma, Chao
Vasudevaraja, Varshini
Serrano, Jonathan
Tong, Jie
Peng, Yansong
Delorenzo, Michael
Shen, Guomiao
Frenster, Joshua
Morales, Renee-Tyler Tan
Qian, Weiyi
Tsirigos, Aristotelis
Chi, Andrew S
Jain, Rajan
Kurz, Sylvia C
Sulman, Erik P
Placantonakis, Dimitris G
Snuderl, Matija
Chen, Weiqiang
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_17d5105f91be4e3ab42eceb0226f07ee
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_17d5105f91be4e3ab42eceb0226f07ee
Other Identifiers
ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.52253
