Structure-guided microbial targeting of antistaphylococcal prodrugs
Structure-guided microbial targeting of antistaphylococcal prodrugs
About this item
Full title
Author / Creator
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS) , Miller, Justin J , Shah, Ishaan T , Hatten, Jayda , Barekatain, Yasaman , Mueller, Elizabeth A , Moustafa, Ahmed M , Edwards, Rachel L , Dowd, Cynthia S , Hoops, Geoffrey C , Johnson, R Jeremy , Planet, Paul J , Muller, Florian L , Jez, Joseph M and Odom John, Audrey R
Publisher
England: eLife Science Publications, Ltd
Journal title
Language
English
Formats
Publication information
Publisher
England: eLife Science Publications, Ltd
Subjects
More information
Scope and Contents
Contents
Carboxy ester prodrugs are widely employed to increase oral absorption and potency of phosphonate antibiotics. Prodrugging can mask problematic chemical features that prevent cellular uptake and may enable tissue-specific compound delivery. However, many carboxy ester promoieties are rapidly hydrolyzed by serum esterases, limiting their therapeutic...
Alternative Titles
Full title
Structure-guided microbial targeting of antistaphylococcal prodrugs
Authors, Artists and Contributors
Author / Creator
Miller, Justin J
Shah, Ishaan T
Hatten, Jayda
Barekatain, Yasaman
Mueller, Elizabeth A
Moustafa, Ahmed M
Edwards, Rachel L
Dowd, Cynthia S
Hoops, Geoffrey C
Johnson, R Jeremy
Planet, Paul J
Muller, Florian L
Jez, Joseph M
Odom John, Audrey R
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_17f733fe025245b6a2dbe45ff732edb9
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_17f733fe025245b6a2dbe45ff732edb9
Other Identifiers
ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.66657
