Impaired branched chain amino acid oxidation contributes to cardiac insulin resistance in heart fail...
Impaired branched chain amino acid oxidation contributes to cardiac insulin resistance in heart failure
About this item
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Author / Creator
Uddin, Golam M. , Zhang, Liyan , Shah, Saumya , Fukushima, Arata , Wagg, Cory S. , Gopal, Keshav , Al Batran, Rami , Pherwani, Simran , Ho, Kim L. , Boisvenue, Jamie , Karwi, Qutuba G. , Altamimi, Tariq , Wishart, David S. , Dyck, Jason R. B. , Ussher, John R. , Oudit, Gavin Y. and Lopaschuk, Gary D.
Publisher
England: BioMed Central Ltd
Journal title
Language
English
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Publication information
Publisher
England: BioMed Central Ltd
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More information
Scope and Contents
Contents
Branched chain amino acids (BCAA) can impair insulin signaling, and cardiac insulin resistance can occur in the failing heart. We, therefore, determined if cardiac BCAA accumulation occurs in patients with dilated cardiomyopathy (DCM), due to an impaired catabolism of BCAA, and if stimulating cardiac BCAA oxidation can improve cardiac function in m...
Alternative Titles
Full title
Impaired branched chain amino acid oxidation contributes to cardiac insulin resistance in heart failure
Authors, Artists and Contributors
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_1825257d7b364b2bb61f4a044c96565b
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_1825257d7b364b2bb61f4a044c96565b
Other Identifiers
ISSN
1475-2840
E-ISSN
1475-2840
DOI
10.1186/s12933-019-0892-3
