SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators inc...
SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4
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Full title
Author / Creator
Tzelepis, Konstantinos , De Braekeleer, Etienne , Aspris, Demetrios , Barbieri, Isaia , Vijayabaskar, M. S. , Liu, Wen-Hsin , Gozdecka, Malgorzata , Metzakopian, Emmanouil , Toop, Hamish D. , Dudek, Monika , Robson, Samuel C. , Hermida-Prado, Francisco , Yang, Yu Hsuen , Babaei-Jadidi, Roya , Garyfallos, Dimitrios A. , Ponstingl, Hannes , Dias, Joao M. L. , Gallipoli, Paolo , Seiler, Michael , Buonamici, Silvia , Vick, Binje , Bannister, Andrew J. , Rad, Roland , Prinjha, Rab K. , Marioni, John C. , Huntly, Brian , Batson, Jennifer , Morris, Jonathan C. , Pina, Cristina , Bradley, Allan , Jeremias, Irmela , Bates, David O. , Yusa, Kosuke , Kouzarides, Tony and Vassiliou, George S.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
We recently identified the splicing kinase gene
SRPK1
as a genetic vulnerability of acute myeloid leukemia (AML). Here, we show that genetic or pharmacological inhibition of SRPK1 leads to cell cycle arrest, leukemic cell differentiation and prolonged survival of mice transplanted with
MLL
-rearranged AML. RNA-seq analysis demonstrates...
Alternative Titles
Full title
SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4
Authors, Artists and Contributors
Author / Creator
De Braekeleer, Etienne
Aspris, Demetrios
Barbieri, Isaia
Vijayabaskar, M. S.
Liu, Wen-Hsin
Gozdecka, Malgorzata
Metzakopian, Emmanouil
Toop, Hamish D.
Dudek, Monika
Robson, Samuel C.
Hermida-Prado, Francisco
Yang, Yu Hsuen
Babaei-Jadidi, Roya
Garyfallos, Dimitrios A.
Ponstingl, Hannes
Dias, Joao M. L.
Gallipoli, Paolo
Seiler, Michael
Buonamici, Silvia
Vick, Binje
Bannister, Andrew J.
Rad, Roland
Prinjha, Rab K.
Marioni, John C.
Huntly, Brian
Batson, Jennifer
Morris, Jonathan C.
Pina, Cristina
Bradley, Allan
Jeremias, Irmela
Bates, David O.
Yusa, Kosuke
Kouzarides, Tony
Vassiliou, George S.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_1853a1ced0ff46dfaf75bec9896c8581
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_1853a1ced0ff46dfaf75bec9896c8581
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-07620-0
