Immune cell topography predicts response to PD-1 blockade in cutaneous T cell lymphoma
Immune cell topography predicts response to PD-1 blockade in cutaneous T cell lymphoma
About this item
Full title
Author / Creator
Phillips, Darci , Matusiak, Magdalena , Gutierrez, Belén Rivero , Bhate, Salil S. , Barlow, Graham L. , Jiang, Sizun , Demeter, Janos , Smythe, Kimberly S. , Pierce, Robert H. , Fling, Steven P. , Ramchurren, Nirasha , Cheever, Martin A. , Goltsev, Yury , West, Robert B. , Khodadoust, Michael S. , Kim, Youn H. , Schürch, Christian M. and Nolan, Garry P.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Cutaneous T cell lymphomas (CTCL) are rare but aggressive cancers without effective treatments. While a subset of patients derive benefit from PD-1 blockade, there is a critically unmet need for predictive biomarkers of response. Herein, we perform CODEX multiplexed tissue imaging and RNA sequencing on 70 tumor regions from 14 advanced CTCL patient...
Alternative Titles
Full title
Immune cell topography predicts response to PD-1 blockade in cutaneous T cell lymphoma
Authors, Artists and Contributors
Author / Creator
Matusiak, Magdalena
Gutierrez, Belén Rivero
Bhate, Salil S.
Barlow, Graham L.
Jiang, Sizun
Demeter, Janos
Smythe, Kimberly S.
Pierce, Robert H.
Fling, Steven P.
Ramchurren, Nirasha
Cheever, Martin A.
Goltsev, Yury
West, Robert B.
Khodadoust, Michael S.
Kim, Youn H.
Schürch, Christian M.
Nolan, Garry P.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_185b95b3ae0241efb2f75ef0ed8fba8c
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_185b95b3ae0241efb2f75ef0ed8fba8c
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-26974-6
