Regulatory mechanisms of immune checkpoints PD-L1 and CTLA-4 in cancer
Regulatory mechanisms of immune checkpoints PD-L1 and CTLA-4 in cancer
About this item
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Author / Creator
Zhang, Hao , Dai, Ziyu , Wu, Wantao , Wang, Zeyu , Zhang, Nan , Zhang, Liyang , Zeng, Wen-Jing , Liu, Zhixiong and Cheng, Quan
Publisher
London: BioMed Central Ltd
Journal title
Language
English
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Publication information
Publisher
London: BioMed Central Ltd
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Scope and Contents
Contents
The cytotoxic T-lymphocyte–associated antigen 4 (CTLA-4)/B7 and programmed death 1 (PD-1)/ programmed cell death-ligand 1 (PD-L1) are two most representative immune checkpoint pathways, which negatively regulate T cell immune function during different phases of T-cell activation. Inhibitors targeting CTLA-4/B7 and PD1/PD-L1 pathways have revolution...
Alternative Titles
Full title
Regulatory mechanisms of immune checkpoints PD-L1 and CTLA-4 in cancer
Authors, Artists and Contributors
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_18b757b7deb14c108ca0a2f289d7ecf8
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_18b757b7deb14c108ca0a2f289d7ecf8
Other Identifiers
ISSN
1756-9966,0392-9078
E-ISSN
1756-9966
DOI
10.1186/s13046-021-01987-7
