Inhibition of integrin αvβ6 sparks T-cell antitumor response and enhances immune checkpoint blockade...
Inhibition of integrin αvβ6 sparks T-cell antitumor response and enhances immune checkpoint blockade therapy in colorectal cancer
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Author / Creator
Busenhart, Philipp , Montalban-Arques, Ana , Katkeviciute, Egle , Morsy, Yasser , Van Passen, Chiara , Hering, Larissa , Atrott, Kirstin , Lang, Silvia , Garzon, Jesus Francisco Glaus , Naschberger, Elisabeth , Hartmann, Arndt , Rogler, Gerhard , Stürzl, Michael , Spalinger, Marianne Rebecca and Scharl, Michael
Publisher
England: BMJ Publishing Group Ltd
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Language
English
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Publisher
England: BMJ Publishing Group Ltd
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BackgroundIntegrin αvβ6 is a heterodimeric cell surface protein whose cellular expression is determined by the availability of the integrin β6 subunit (ITGB6). It is expressed at very low levels in most organs during tissue homeostasis but shows highly upregulated expression during the process of tumorigenesis in many cancers of epithelial origin....
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Full title
Inhibition of integrin αvβ6 sparks T-cell antitumor response and enhances immune checkpoint blockade therapy in colorectal cancer
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TN_cdi_doaj_primary_oai_doaj_org_article_19040f65b7694fdf88048f127a56fc97
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_19040f65b7694fdf88048f127a56fc97
Other Identifiers
ISSN
2051-1426
E-ISSN
2051-1426
DOI
10.1136/jitc-2021-003465
