Development of PVTX-405 as a potent and highly selective molecular glue degrader of IKZF2 for cancer...
Development of PVTX-405 as a potent and highly selective molecular glue degrader of IKZF2 for cancer immunotherapy
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Author / Creator
Chen, Zhixiang , Dhruv, Harshil , Zhang, Xuqing , Rej, Rohan Kalyan , Bai, Longchuan , McEachern, Donna , Kirchhoff, Paul , Nagilla, Rakesh , Jolivette, Larry J. , Rice, Cory T. , Orth, Peter , Strickland, Corey O. , Priestley, E. Scott , Mohammad, Helai P. , Wang, Meilin , Wen, Bo , Sun, Duxin , Sui, Zhihua and Wang, Shaomeng
Publisher
London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Contents
IKZF2 (Helios) is a transcription factor that is selectively expressed by Tregs and is essential for preserving the function and stability of Tregs in the tumor microenvironment (TME), where it suppresses the anti-tumor immune response. Targeted IKZF2 degradation by small molecules represents a promising strategy for the development of a new class...
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Full title
Development of PVTX-405 as a potent and highly selective molecular glue degrader of IKZF2 for cancer immunotherapy
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TN_cdi_doaj_primary_oai_doaj_org_article_199be24f920f44d1bd5fcae2e7f1e83c
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_199be24f920f44d1bd5fcae2e7f1e83c
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-025-58431-z
