Targeting GLP-1 receptor trafficking to improve agonist efficacy
Targeting GLP-1 receptor trafficking to improve agonist efficacy
About this item
Full title
Author / Creator
Jones, Ben , Buenaventura, Teresa , Kanda, Nisha , Chabosseau, Pauline , Owen, Bryn M. , Scott, Rebecca , Goldin, Robert , Angkathunyakul, Napat , Corrêa Jr, Ivan R. , Bosco, Domenico , Johnson, Paul R. , Piemonti, Lorenzo , Marchetti, Piero , Shapiro, A. M. James , Cochran, Blake J. , Hanyaloglu, Aylin C. , Inoue, Asuka , Tan, Tricia , Rutter, Guy A. , Tomas, Alejandra and Bloom, Stephen R.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Glucagon-like peptide-1 receptor (GLP-1R) activation promotes insulin secretion from pancreatic beta cells, causes weight loss, and is an important pharmacological target in type 2 diabetes (T2D). Like other G protein-coupled receptors, the GLP-1R undergoes agonist-mediated endocytosis, but the functional and therapeutic consequences of modulating...
Alternative Titles
Full title
Targeting GLP-1 receptor trafficking to improve agonist efficacy
Authors, Artists and Contributors
Author / Creator
Buenaventura, Teresa
Kanda, Nisha
Chabosseau, Pauline
Owen, Bryn M.
Scott, Rebecca
Goldin, Robert
Angkathunyakul, Napat
Corrêa Jr, Ivan R.
Bosco, Domenico
Johnson, Paul R.
Piemonti, Lorenzo
Marchetti, Piero
Shapiro, A. M. James
Cochran, Blake J.
Hanyaloglu, Aylin C.
Inoue, Asuka
Tan, Tricia
Rutter, Guy A.
Tomas, Alejandra
Bloom, Stephen R.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_1a1126743c294faca93a0169f9e7cb17
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_1a1126743c294faca93a0169f9e7cb17
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-03941-2
