A zebrafish screen reveals Renin-angiotensin system inhibitors as neuroprotective via mitochondrial...
A zebrafish screen reveals Renin-angiotensin system inhibitors as neuroprotective via mitochondrial restoration in dopamine neurons
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Author / Creator
Kim, Gha-Hyun J , Mo, Han , Liu, Harrison , Wu, Zhihao , Chen, Steven , Zheng, Jiashun , Zhao, Xiang , Nucum, Daryl , Shortland, James , Peng, Longping , Elepano, Mannuel , Tang, Benjamin , Olson, Steven , Paras, Nick , Li, Hao , Renslo, Adam R , Arkin, Michelle R , Huang, Bo , Lu, Bingwei , Sirota, Marina and Guo, Su
Publisher
England: eLife Sciences Publications Ltd
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Language
English
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Publisher
England: eLife Sciences Publications Ltd
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Contents
Parkinson's disease (PD) is a common neurodegenerative disorder without effective disease-modifying therapeutics. Here, we establish a chemogenetic dopamine (DA) neuron ablation model in larval zebrafish with mitochondrial dysfunction and robustness suitable for high-content screening. We use this system to conduct an in vivo DA neuron imaging-base...
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Full title
A zebrafish screen reveals Renin-angiotensin system inhibitors as neuroprotective via mitochondrial restoration in dopamine neurons
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TN_cdi_doaj_primary_oai_doaj_org_article_1a2b18fbbd014e52b754a5691eee90b7
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_1a2b18fbbd014e52b754a5691eee90b7
Other Identifiers
ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.69795
