Lactate activates trained immunity by fueling the tricarboxylic acid cycle and regulating histone la...
Lactate activates trained immunity by fueling the tricarboxylic acid cycle and regulating histone lactylation
About this item
Full title
Author / Creator
Cai, Huanhuan , Chen, Xueyuan , Liu, Yan , Chen, Yingbo , Zhong, Gechang , Chen, Xiaoyu , Rong, Shuo , Zeng, Hao , Zhang, Lin , Li, Zelong , Liao, Aihua , Zeng, Xiangtai , Xiong, Wei , Guo, Cihang , Zhu, Yanfang , Deng, Ke-Qiong , Ren, Hong , Yan, Huan , Cai, Zeng , Xu, Ke , Zhou, Li , Lu, Zhibing , Wang, Fubing and Liu, Shi
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Trained immunity refers to the long-term memory of the innate immune cells. However, little is known about how environmental nutrient availability influences trained immunity. This study finds that physiologic carbon sources impact glucose contribution to the tricarboxylic acid (TCA) cycle and enhance cytokine production of trained monocytes. Our e...
Alternative Titles
Full title
Lactate activates trained immunity by fueling the tricarboxylic acid cycle and regulating histone lactylation
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_1a5fead389f04f899d030b646152c730
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_1a5fead389f04f899d030b646152c730
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-025-58563-2
