A first-in-human phase 1/2 study of FGF401 and combination of FGF401 with spartalizumab in patients...
A first-in-human phase 1/2 study of FGF401 and combination of FGF401 with spartalizumab in patients with hepatocellular carcinoma or biomarker-selected solid tumors
About this item
Full title
Author / Creator
Chan, Stephen L. , Schuler, Martin , Kang, Yoon-Koo , Yen, Chia-Jui , Edeline, Julien , Choo, Su Pin , Lin, Chia-Chi , Okusaka, Takuji , Weiss, Karl-Heinz , Macarulla, Teresa , Cattan, Stéphane , Blanc, Jean-Frederic , Lee, Kyung-Hun , Maur, Michela , Pant, Shubham , Kudo, Masatoshi , Assenat, Eric , Zhu, Andrew X. , Yau, Thomas , Lim, Ho Yeong , Bruix, Jordi , Geier, Andreas , Guillén-Ponce, Carmen , Fasolo, Angelica , Finn, Richard S. , Fan, Jia , Vogel, Arndt , Qin, Shukui , Riester, Markus , Katsanou, Vasiliki , Chaudhari, Monica , Kakizume, Tomoyuki , Gu, Yi , Porta, Diana Graus , Myers, Andrea and Delord, Jean-Pierre
Publisher
London: BioMed Central
Journal title
Language
English
Formats
Publication information
Publisher
London: BioMed Central
Subjects
More information
Scope and Contents
Contents
Background
Deregulation of FGF19-FGFR4 signaling is found in several cancers, including hepatocellular carcinoma (HCC), nominating it for therapeutic targeting. FGF401 is a potent, selective FGFR4 inhibitor with antitumor activity in preclinical models. This study was designed to determine the recommended phase 2 dose (RP2D), characterize PK/PD,...
Alternative Titles
Full title
A first-in-human phase 1/2 study of FGF401 and combination of FGF401 with spartalizumab in patients with hepatocellular carcinoma or biomarker-selected solid tumors
Authors, Artists and Contributors
Author / Creator
Schuler, Martin
Kang, Yoon-Koo
Yen, Chia-Jui
Edeline, Julien
Choo, Su Pin
Lin, Chia-Chi
Okusaka, Takuji
Weiss, Karl-Heinz
Macarulla, Teresa
Cattan, Stéphane
Blanc, Jean-Frederic
Lee, Kyung-Hun
Maur, Michela
Pant, Shubham
Kudo, Masatoshi
Assenat, Eric
Zhu, Andrew X.
Yau, Thomas
Lim, Ho Yeong
Bruix, Jordi
Geier, Andreas
Guillén-Ponce, Carmen
Fasolo, Angelica
Finn, Richard S.
Fan, Jia
Vogel, Arndt
Qin, Shukui
Riester, Markus
Katsanou, Vasiliki
Chaudhari, Monica
Kakizume, Tomoyuki
Gu, Yi
Porta, Diana Graus
Myers, Andrea
Delord, Jean-Pierre
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_1a80d93b46254b83bfdf5d4c0de1a368
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_1a80d93b46254b83bfdf5d4c0de1a368
Other Identifiers
ISSN
1756-9966,0392-9078
E-ISSN
1756-9966
DOI
10.1186/s13046-022-02383-5
