Targeting Treg cells with GITR activation alleviates resistance to immunotherapy in murine glioblast...
Targeting Treg cells with GITR activation alleviates resistance to immunotherapy in murine glioblastomas
About this item
Full title
Author / Creator
Amoozgar, Zohreh , Kloepper, Jonas , Ren, Jun , Tay, Rong En , Kazer, Samuel W. , Kiner, Evgeny , Krishnan, Shanmugarajan , Posada, Jessica M. , Ghosh, Mitrajit , Mamessier, Emilie , Wong, Christina , Ferraro, Gino B. , Batista, Ana , Wang, Nancy , Badeaux, Mark , Roberge, Sylvie , Xu, Lei , Huang, Peigen , Shalek, Alex K. , Fukumura, Dai , Kim, Hye-Jung and Jain, Rakesh K.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Immune checkpoint blockers (ICBs) have failed in all phase III glioblastoma (GBM) trials. Here, we show that regulatory T (Treg) cells play a key role in GBM resistance to ICBs in experimental gliomas. Targeting glucocorticoid-induced TNFR-related receptor (GITR) in Treg cells using an agonistic antibody (αGITR) promotes CD4 Treg cell differentiati...
Alternative Titles
Full title
Targeting Treg cells with GITR activation alleviates resistance to immunotherapy in murine glioblastomas
Authors, Artists and Contributors
Author / Creator
Kloepper, Jonas
Ren, Jun
Tay, Rong En
Kazer, Samuel W.
Kiner, Evgeny
Krishnan, Shanmugarajan
Posada, Jessica M.
Ghosh, Mitrajit
Mamessier, Emilie
Wong, Christina
Ferraro, Gino B.
Batista, Ana
Wang, Nancy
Badeaux, Mark
Roberge, Sylvie
Xu, Lei
Huang, Peigen
Shalek, Alex K.
Fukumura, Dai
Kim, Hye-Jung
Jain, Rakesh K.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_1ab21691b67f4af6a88731fc02b3c2eb
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_1ab21691b67f4af6a88731fc02b3c2eb
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-22885-8
