MBNL1 regulates essential alternative RNA splicing patterns in MLL-rearranged leukemia
MBNL1 regulates essential alternative RNA splicing patterns in MLL-rearranged leukemia
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Despite growing awareness of the biologic features underlying MLL-rearranged leukemia, targeted therapies for this leukemia have remained elusive and clinical outcomes remain dismal. MBNL1, a protein involved in alternative splicing, is consistently overexpressed in MLL-rearranged leukemias. We found that MBNL1 loss significantly impairs propagatio...
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Full title
MBNL1 regulates essential alternative RNA splicing patterns in MLL-rearranged leukemia
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TN_cdi_doaj_primary_oai_doaj_org_article_1b153388c9a248a7aa9ef84624fc49dd
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_1b153388c9a248a7aa9ef84624fc49dd
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-15733-8
