Expression of β-globin by cancer cells promotes cell survival during blood-borne dissemination
Expression of β-globin by cancer cells promotes cell survival during blood-borne dissemination
About this item
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Author / Creator
Zheng, Yu , Miyamoto, David T. , Wittner, Ben S. , Sullivan, James P. , Aceto, Nicola , Jordan, Nicole Vincent , Yu, Min , Karabacak, Nezihi Murat , Comaills, Valentine , Morris, Robert , Desai, Rushil , Desai, Niyati , Emmons, Erin , Milner, John D. , Lee, Richard J. , Wu, Chin-Lee , Sequist, Lecia V. , Haas, Wilhelm , Ting, David T. , Toner, Mehmet , Ramaswamy, Sridhar , Maheswaran, Shyamala and Haber, Daniel A.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Metastasis-competent circulating tumour cells (CTCs) experience oxidative stress in the bloodstream, but their survival mechanisms are not well defined. Here, comparing single-cell RNA-Seq profiles of CTCs from breast, prostate and lung cancers, we observe consistent induction of β-globin (
HBB
), but not its partner α-globin (
HBA
). T...
Alternative Titles
Full title
Expression of β-globin by cancer cells promotes cell survival during blood-borne dissemination
Authors, Artists and Contributors
Author / Creator
Miyamoto, David T.
Wittner, Ben S.
Sullivan, James P.
Aceto, Nicola
Jordan, Nicole Vincent
Yu, Min
Karabacak, Nezihi Murat
Comaills, Valentine
Morris, Robert
Desai, Rushil
Desai, Niyati
Emmons, Erin
Milner, John D.
Lee, Richard J.
Wu, Chin-Lee
Sequist, Lecia V.
Haas, Wilhelm
Ting, David T.
Toner, Mehmet
Ramaswamy, Sridhar
Maheswaran, Shyamala
Haber, Daniel A.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_1b34881d11b34839baa13a42e1ec312c
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_1b34881d11b34839baa13a42e1ec312c
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms14344
