Celastrol mitigates inflammation in sepsis by inhibiting the PKM2-dependent Warburg effect
Celastrol mitigates inflammation in sepsis by inhibiting the PKM2-dependent Warburg effect
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Author / Creator
Luo, Piao , Zhang, Qian , Zhong, Tian-Yu , Chen, Jia-Yun , Zhang, Jun-Zhe , Tian, Ya , Zheng, Liu-Hai , Yang, Fan , Dai, Ling-Yun , Zou, Chang , Li, Zhi-Jie , Liu, Jing-Hua and Wang, Ji-Gang
Publisher
England: BioMed Central Ltd
Journal title
Language
English
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Publication information
Publisher
England: BioMed Central Ltd
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Scope and Contents
Contents
Sepsis involves life-threatening organ dysfunction and is caused by a dysregulated host response to infection. No specific therapies against sepsis have been reported. Celastrol (Cel) is a natural anti-inflammatory compound that shows potential against systemic inflammatory diseases. This study aimed to investigate the pharmacological activity and...
Alternative Titles
Full title
Celastrol mitigates inflammation in sepsis by inhibiting the PKM2-dependent Warburg effect
Authors, Artists and Contributors
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_1b598b7ec7c04be6ac1055d971c085d7
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_1b598b7ec7c04be6ac1055d971c085d7
Other Identifiers
ISSN
2054-9369,2095-7467
E-ISSN
2054-9369
DOI
10.1186/s40779-022-00381-4
