Purine metabolism regulates DNA repair and therapy resistance in glioblastoma
Purine metabolism regulates DNA repair and therapy resistance in glioblastoma
About this item
Full title
Author / Creator
Zhou, Weihua , Yao, Yangyang , Scott, Andrew J. , Wilder-Romans, Kari , Dresser, Joseph J. , Werner, Christian K. , Sun, Hanshi , Pratt, Drew , Sajjakulnukit, Peter , Zhao, Shuang G. , Davis, Mary , Nelson, Barbara S. , Halbrook, Christopher J. , Zhang, Li , Gatto, Francesco , Umemura, Yoshie , Walker, Angela K. , Kachman, Maureen , Sarkaria, Jann N. , Xiong, Jianping , Morgan, Meredith A. , Rehemtualla, Alnawaz , Castro, Maria G. , Lowenstein, Pedro , Chandrasekaran, Sriram , Lawrence, Theodore S. , Lyssiotis, Costas A. and Wahl, Daniel R.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Intratumoral genomic heterogeneity in glioblastoma (GBM) is a barrier to overcoming therapy resistance. Treatments that are effective independent of genotype are urgently needed. By correlating intracellular metabolite levels with radiation resistance across dozens of genomically-distinct models of GBM, we find that purine metabolites, especially g...
Alternative Titles
Full title
Purine metabolism regulates DNA repair and therapy resistance in glioblastoma
Authors, Artists and Contributors
Author / Creator
Yao, Yangyang
Scott, Andrew J.
Wilder-Romans, Kari
Dresser, Joseph J.
Werner, Christian K.
Sun, Hanshi
Pratt, Drew
Sajjakulnukit, Peter
Zhao, Shuang G.
Davis, Mary
Nelson, Barbara S.
Halbrook, Christopher J.
Zhang, Li
Gatto, Francesco
Umemura, Yoshie
Walker, Angela K.
Kachman, Maureen
Sarkaria, Jann N.
Xiong, Jianping
Morgan, Meredith A.
Rehemtualla, Alnawaz
Castro, Maria G.
Lowenstein, Pedro
Chandrasekaran, Sriram
Lawrence, Theodore S.
Lyssiotis, Costas A.
Wahl, Daniel R.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_1b59daa1bcd04cf3a9e4d552dbc954ba
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_1b59daa1bcd04cf3a9e4d552dbc954ba
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-17512-x
