Engineered E. coli Nissle 1917 for delivery of bioactive IL-2 for cancer immunotherapy
Engineered E. coli Nissle 1917 for delivery of bioactive IL-2 for cancer immunotherapy
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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In this study we performed a step-wise optimization of biologically active IL-2 for delivery using
E. coli
Nissle 1917. Engineering of the strain was coupled with an in vitro cell assay to measure the biological activity of microbially produced IL-2 (mi-IL2). Next, we assessed the immune modulatory potential of mi-IL2 using a 3D tumor spheroi...
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Engineered E. coli Nissle 1917 for delivery of bioactive IL-2 for cancer immunotherapy
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TN_cdi_doaj_primary_oai_doaj_org_article_1b7a75507437425b9f7c1544ff1af6d3
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_1b7a75507437425b9f7c1544ff1af6d3
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-023-39365-2
