FBXW2 suppresses migration and invasion of lung cancer cells via promoting β-catenin ubiquitylation...
FBXW2 suppresses migration and invasion of lung cancer cells via promoting β-catenin ubiquitylation and degradation
About this item
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Author / Creator
Yang, Fei , Xu, Jie , Li, Hua , Tan, Mingjia , Xiong, Xiufang and Sun, Yi
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
FBXW2 inhibits proliferation of lung cancer cells by targeting SKP2 for degradation. Whether and how FBXW2 regulates tumor invasion and metastasis is previously unknown. Here, we report that FBXW2 is an E3 ligase for β-catenin. FBXW2 binds to β-catenin upon EGF-AKT1-mediated phosphorylation on Ser
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, and promotes its ubiquitylation and deg...
Alternative Titles
Full title
FBXW2 suppresses migration and invasion of lung cancer cells via promoting β-catenin ubiquitylation and degradation
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_1bdd0e3ba0f94b198831ab812a2cd975
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_1bdd0e3ba0f94b198831ab812a2cd975
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-09289-5
