Nanodiamond autophagy inhibitor allosterically improves the arsenical-based therapy of solid tumors
Nanodiamond autophagy inhibitor allosterically improves the arsenical-based therapy of solid tumors
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Author / Creator
Cui, Zhifen , Zhang, Yu , Xia, Kai , Yan, Qinglong , Kong, Huating , Zhang, Jichao , Zuo, Xiaolei , Shi, Jiye , Wang, Lihua , Zhu, Ying and Fan, Chunhai
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Contents
Arsenic trioxide (ATO) is a successful chemotherapeutic drug for blood cancers via selective induction of apoptosis; however its efficacy in solid tumors is limited. Here we repurpose nanodiamonds (NDs) as a safe and potent autophagic inhibitor to allosterically improve the therapeutic efficacy of ATO-based treatment in solid tumors. We find that N...
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Full title
Nanodiamond autophagy inhibitor allosterically improves the arsenical-based therapy of solid tumors
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_1bf72d2d168c489c90f7ceab014ac31a
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_1bf72d2d168c489c90f7ceab014ac31a
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-06749-2
