Gut microbe-targeted choline trimethylamine lyase inhibition improves obesity via rewiring of host c...
Gut microbe-targeted choline trimethylamine lyase inhibition improves obesity via rewiring of host circadian rhythms
About this item
Full title
Author / Creator
Schugar, Rebecca C , Gliniak, Christy M , Osborn, Lucas J , Massey, William , Sangwan, Naseer , Horak, Anthony , Banerjee, Rakhee , Orabi, Danny , Helsley, Robert N , Brown, Amanda L , Burrows, Amy , Finney, Chelsea , Fung, Kevin K , Allen, Frederick M , Ferguson, Daniel , Gromovsky, Anthony D , Neumann, Chase , Cook, Kendall , McMillan, Amy , Buffa, Jennifer A , Anderson, James T , Mehrabian, Margarete , Goudarzi, Maryam , Willard, Belinda , Mak, Tytus D , Armstrong, Andrew R , Swanson, Garth , Keshavarzian, Ali , Garcia-Garcia, Jose Carlos , Wang, Zeneng , Lusis, Aldons J , Hazen, Stanley L and Brown, Jonathan Mark
Publisher
England: eLife Sciences Publications Ltd
Journal title
Language
English
Formats
Publication information
Publisher
England: eLife Sciences Publications Ltd
Subjects
More information
Scope and Contents
Contents
Obesity has repeatedly been linked to reorganization of the gut microbiome, yet to this point obesity therapeutics have been targeted exclusively toward the human host. Here, we show that gut microbe-targeted inhibition of the trimethylamine N-oxide (TMAO) pathway protects mice against the metabolic disturbances associated with diet-induced obesity...
Alternative Titles
Full title
Gut microbe-targeted choline trimethylamine lyase inhibition improves obesity via rewiring of host circadian rhythms
Authors, Artists and Contributors
Author / Creator
Gliniak, Christy M
Osborn, Lucas J
Massey, William
Sangwan, Naseer
Horak, Anthony
Banerjee, Rakhee
Orabi, Danny
Helsley, Robert N
Brown, Amanda L
Burrows, Amy
Finney, Chelsea
Fung, Kevin K
Allen, Frederick M
Ferguson, Daniel
Gromovsky, Anthony D
Neumann, Chase
Cook, Kendall
McMillan, Amy
Buffa, Jennifer A
Anderson, James T
Mehrabian, Margarete
Goudarzi, Maryam
Willard, Belinda
Mak, Tytus D
Armstrong, Andrew R
Swanson, Garth
Keshavarzian, Ali
Garcia-Garcia, Jose Carlos
Wang, Zeneng
Lusis, Aldons J
Hazen, Stanley L
Brown, Jonathan Mark
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_1bf775b855894d52aa435ffcd48a01d8
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_1bf775b855894d52aa435ffcd48a01d8
Other Identifiers
ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.63998
