Anti-sortilin1 Antibody Up-Regulates Progranulin via Sortilin1 Down-Regulation
Anti-sortilin1 Antibody Up-Regulates Progranulin via Sortilin1 Down-Regulation
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Publisher
Switzerland: Frontiers Research Foundation
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Language
English
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Publisher
Switzerland: Frontiers Research Foundation
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Contents
Progranulin (PGRN) haploinsufficiency associated with loss-of-function mutations in the granulin gene causes frontotemporal dementia (FTD). This suggests that increasing PGRN levels could have promising therapeutic implications for patients carrying
GRN
mutations. In this study, we explored the therapeutic potential of sortilin1 (SORT1), a cl...
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Full title
Anti-sortilin1 Antibody Up-Regulates Progranulin via Sortilin1 Down-Regulation
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TN_cdi_doaj_primary_oai_doaj_org_article_1bfd1d0933a04c75b1f1c53ea0ed5fe5
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_1bfd1d0933a04c75b1f1c53ea0ed5fe5
Other Identifiers
ISSN
1662-453X,1662-4548
E-ISSN
1662-453X
DOI
10.3389/fnins.2020.586107
