The cryptic lncRNA-encoded microprotein TPM3P9 drives oncogenic RNA splicing and tumorigenesis
The cryptic lncRNA-encoded microprotein TPM3P9 drives oncogenic RNA splicing and tumorigenesis
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Author / Creator
Meng, Kun , Li, Yuying , Yuan, Xiaoyi , Shen, Hui-Min , Hu, Li-Ling , Liu, Danya , Shi, Fujin , Zheng, Dandan , Shi, Xinyu , Wen, Nengqiao , Cao, Yun , Pan, Yun-Long , He, Qing-Yu and Zhang, Chris Zhiyi
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Emerging evidence demonstrates that cryptic translation from RNAs previously annotated as noncoding might generate microproteins with oncogenic functions. However, the importance and underlying mechanisms of these microproteins in alternative splicing-driven tumor progression have rarely been studied. Here, we show that the novel protein TPM3P9, en...
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Full title
The cryptic lncRNA-encoded microprotein TPM3P9 drives oncogenic RNA splicing and tumorigenesis
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TN_cdi_doaj_primary_oai_doaj_org_article_1c255317cc95452bb453596720357516
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_1c255317cc95452bb453596720357516
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ISSN
2059-3635,2095-9907
E-ISSN
2059-3635
DOI
10.1038/s41392-025-02128-8
