Inhibition of eIF5A hypusination reprogrammes metabolism and glucose handling in mouse kidney
Inhibition of eIF5A hypusination reprogrammes metabolism and glucose handling in mouse kidney
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Inhibition of the eukaryotic initiation factor 5A activation by the spermidine analogue GC7 has been shown to protect proximal cells and whole kidneys against an acute episode of ischaemia. The highlighted mechanism involves a metabolic switch from oxidative phosphorylation toward glycolysis allowing cells to be transiently independent of oxygen su...
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Inhibition of eIF5A hypusination reprogrammes metabolism and glucose handling in mouse kidney
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TN_cdi_doaj_primary_oai_doaj_org_article_1c2ead5a19d749b38f91c58c3d62652c
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_1c2ead5a19d749b38f91c58c3d62652c
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ISSN
2041-4889
E-ISSN
2041-4889
DOI
10.1038/s41419-021-03577-z
