SOX2 antagonizes WWC1 to drive YAP1 activation in esophageal squamous cell carcinoma
SOX2 antagonizes WWC1 to drive YAP1 activation in esophageal squamous cell carcinoma
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Author / Creator
Chai, Yuhang , Li, Qihang , Zhao, Hongying , Zhang, Zhiyu , Yu, Xiaodan , Pang, Lijuan , Liu, Zheng , Zhao, Jin , Wang, Lianghai and Li, Feng
Publisher
United States: John Wiley & Sons, Inc
Journal title
Language
English
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Publisher
United States: John Wiley & Sons, Inc
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Scope and Contents
Contents
Whether SOX2 and ACTL6A/TP63 interact with the Hippo‐YAP1 pathway in esophageal squamous cell carcinoma (ESCC) remains unclear. Here, we reveal that SOX2, ACTL6A, and TP63 are co‐amplified and upregulated in ESCC samples. Multiple SOX2 binding peaks in the locus of WWC1, a Hippo‐YAP1 regulator, and an inverse correlation between the expression of S...
Alternative Titles
Full title
SOX2 antagonizes WWC1 to drive YAP1 activation in esophageal squamous cell carcinoma
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TN_cdi_doaj_primary_oai_doaj_org_article_1c5d75588a4f41888f4bc4f050392032
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_1c5d75588a4f41888f4bc4f050392032
Other Identifiers
ISSN
2045-7634
E-ISSN
2045-7634
DOI
10.1002/cam4.2569
