Strategies for Solubility and Bioavailability Enhancement and Toxicity Reduction of Norcantharidin
Strategies for Solubility and Bioavailability Enhancement and Toxicity Reduction of Norcantharidin
About this item
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Author / Creator
Liu, Qian , Sun, Henglai , Li, Xinyu , Sheng, Huagang and Zhu, Liqiao
Publisher
Switzerland: MDPI AG
Journal title
Language
English
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Publication information
Publisher
Switzerland: MDPI AG
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Scope and Contents
Contents
Cantharidin (CTD) is the main active ingredient isolated from Mylabris, and norcantharidin (NCTD) is a demethylated derivative of CTD, which has similar antitumor activity to CTD and lower toxicity than CTD. However, the clinical use of NCTD is limited due to its poor solubility, low bioavailability, and toxic effects on normal cells. To overcome t...
Alternative Titles
Full title
Strategies for Solubility and Bioavailability Enhancement and Toxicity Reduction of Norcantharidin
Authors, Artists and Contributors
Author / Creator
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_1c7b39c060ba408ea2f8636ff00bf449
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_1c7b39c060ba408ea2f8636ff00bf449
Other Identifiers
ISSN
1420-3049
E-ISSN
1420-3049
DOI
10.3390/molecules27227740
