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Primary cilia on muscle stem cells are critical to maintain regenerative capacity and are lost durin...

Primary cilia on muscle stem cells are critical to maintain regenerative capacity and are lost durin...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_1cb547b9df374953936e2d5fd08f29bc

Primary cilia on muscle stem cells are critical to maintain regenerative capacity and are lost during aging

About this item

Full title

Primary cilia on muscle stem cells are critical to maintain regenerative capacity and are lost during aging

Publisher

London: Nature Publishing Group UK

Journal title

Nature communications, 2022-03, Vol.13 (1), p.1439-1439, Article 1439

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

During aging, the regenerative capacity of muscle stem cells (MuSCs) decreases, diminishing the ability of muscle to repair following injury. We found that the ability of MuSCs to regenerate is regulated by the primary cilium, a cellular protrusion that serves as a sensitive sensory organelle. Abolishing MuSC cilia inhibited MuSC proliferation in v...

Alternative Titles

Full title

Primary cilia on muscle stem cells are critical to maintain regenerative capacity and are lost during aging

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_1cb547b9df374953936e2d5fd08f29bc

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_1cb547b9df374953936e2d5fd08f29bc

Other Identifiers

ISSN

2041-1723

E-ISSN

2041-1723

DOI

10.1038/s41467-022-29150-6

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