Basmisanil, a highly selective GABAA-α5 negative allosteric modulator: preclinical pharmacology and...
Basmisanil, a highly selective GABAA-α5 negative allosteric modulator: preclinical pharmacology and demonstration of functional target engagement in man
About this item
Full title
Author / Creator
Hipp, Joerg F. , Knoflach, Frederic , Comley, Robert , Ballard, Theresa M. , Honer, Michael , Trube, Gerhard , Gasser, Rodolfo , Prinssen, Eric , Wallace, Tanya L. , Rothfuss, Andreas , Knust, Henner , Lennon-Chrimes, Sian , Derks, Michael , Bentley, Darren , Squassante, Lisa , Nave, Stephane , Nöldeke, Jana , Wandel, Christoph , Thomas, Andrew W. and Hernandez, Maria-Clemencia
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
GABA
A
-α5 subunit-containing receptors have been shown to play a key modulatory role in cognition and represent a promising drug target for cognitive dysfunction, as well as other disorders. Here we report on the preclinical and early clinical profile of a novel GABA
A
-α5 selective negative allosteric modulator (NAM), basmisanil, whic...
Alternative Titles
Full title
Basmisanil, a highly selective GABAA-α5 negative allosteric modulator: preclinical pharmacology and demonstration of functional target engagement in man
Authors, Artists and Contributors
Author / Creator
Knoflach, Frederic
Comley, Robert
Ballard, Theresa M.
Honer, Michael
Trube, Gerhard
Gasser, Rodolfo
Prinssen, Eric
Wallace, Tanya L.
Rothfuss, Andreas
Knust, Henner
Lennon-Chrimes, Sian
Derks, Michael
Bentley, Darren
Squassante, Lisa
Nave, Stephane
Nöldeke, Jana
Wandel, Christoph
Thomas, Andrew W.
Hernandez, Maria-Clemencia
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_1cc826ca236941e185deaad9d64c993b
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_1cc826ca236941e185deaad9d64c993b
Other Identifiers
ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-021-87307-7
