BMP restricts stemness of intestinal Lgr5+ stem cells by directly suppressing their signature genes
BMP restricts stemness of intestinal Lgr5+ stem cells by directly suppressing their signature genes
About this item
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Author / Creator
Qi, Zhen , Li, Yehua , Zhao, Bing , Xu, Chi , Liu, Yuan , Li, Haonan , Zhang, Bingjie , Wang, Xinquan , Yang, Xiao , Xie, Wei , Li, Baojie , Han, Jing-Dong Jackie and Chen, Ye-Guang
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
The intestinal epithelium possesses a remarkable self-renewal ability, which is mediated by actively proliferating Lgr5
+
stem cells. Bone morphogenetic protein (BMP) signalling represents one major counterforce that limits the hyperproliferation of intestinal epithelium, but the exact mechanism remains elusive. Here we demonstrate that epith...
Alternative Titles
Full title
BMP restricts stemness of intestinal Lgr5+ stem cells by directly suppressing their signature genes
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_1cfafbf39370423c97491755711f11d9
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_1cfafbf39370423c97491755711f11d9
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms13824
