Myosin X is recruited to nascent focal adhesions at the leading edge and induces multi-cycle filopod...
Myosin X is recruited to nascent focal adhesions at the leading edge and induces multi-cycle filopodial elongation
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Filopodia protrude from the leading edge of cells and play important roles in cell motility. Here we report the mechanism of myosin X (encoded by Myo10)-induced multi-cycle filopodia extension. We found that actin, Arp2/3, vinculin and integrin-β first accumulated at the cell’s leading edge. Myosin X was then gathered at these sites, gradually clus...
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Myosin X is recruited to nascent focal adhesions at the leading edge and induces multi-cycle filopodial elongation
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TN_cdi_doaj_primary_oai_doaj_org_article_1d9aaba67a494c1db325ab4a0b2f6467
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_1d9aaba67a494c1db325ab4a0b2f6467
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-017-06147-6
