SerpinE1 drives a cell-autonomous pathogenic signaling in Hutchinson–Gilford progeria syndrome
SerpinE1 drives a cell-autonomous pathogenic signaling in Hutchinson–Gilford progeria syndrome
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London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Hutchinson–Gilford progeria syndrome (HGPS) is a rare, fatal disease caused by
Lamin A
mutation, leading to altered nuclear architecture, loss of peripheral heterochromatin and deregulated gene expression. HGPS patients eventually die by coronary artery disease and cardiovascular alterations. Yet, how deregulated transcriptional networks at t...
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Full title
SerpinE1 drives a cell-autonomous pathogenic signaling in Hutchinson–Gilford progeria syndrome
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TN_cdi_doaj_primary_oai_doaj_org_article_1e6acf5c75d44b15ac9788368d8e3b13
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_1e6acf5c75d44b15ac9788368d8e3b13
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ISSN
2041-4889
E-ISSN
2041-4889
DOI
10.1038/s41419-022-05168-y
