Binding to nucleosome poises human SIRT6 for histone H3 deacetylation
Binding to nucleosome poises human SIRT6 for histone H3 deacetylation
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England: eLife Sciences Publications Ltd
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English
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England: eLife Sciences Publications Ltd
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Sirtuin 6 (SIRT6) is an NAD
-dependent histone H3 deacetylase that is prominently found associated with chromatin, attenuates transcriptionally active promoters and regulates DNA repair, metabolic homeostasis and lifespan. Unlike other sirtuins, it has low affinity to free histone tails but demonstrates strong binding to nucleosomes. It is poorl...
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Full title
Binding to nucleosome poises human SIRT6 for histone H3 deacetylation
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TN_cdi_doaj_primary_oai_doaj_org_article_1e6b6b06a7b744acbbeadc0ce34b2a17
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_1e6b6b06a7b744acbbeadc0ce34b2a17
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.87989
