Radiation to all macroscopic sites of tumor permits greater systemic antitumor response to in situ v...
Radiation to all macroscopic sites of tumor permits greater systemic antitumor response to in situ vaccination
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Author / Creator
Carlson, Peter M , Patel, Ravi B , Birstler, Jen , Rodriquez, Matthew , Sun, Claire , Erbe, Amy K , Bates, Amber M , Marsh, Ian , Grudzinski, Joseph , Hernandez, Reinier , Pieper, Alexander A , Feils, Arika S , Rakhmilevich, Alexander L , Weichert, Jamey P , Bednarz, Bryan P , Sondel, Paul M and Morris, Zachary S
Publisher
England: BMJ Publishing Group Ltd
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Language
English
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Publisher
England: BMJ Publishing Group Ltd
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Contents
BackgroundThe antitumor effects of external beam radiation therapy (EBRT) are mediated, in part, by an immune response. We have reported that a single fraction of 12 Gy EBRT combined with intratumoral anti-GD2 hu14.18-IL2 immunocytokine (IC) generates an effective in situ vaccine (ISV) against GD2-positive murine tumors. This ISV is effective in er...
Alternative Titles
Full title
Radiation to all macroscopic sites of tumor permits greater systemic antitumor response to in situ vaccination
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TN_cdi_doaj_primary_oai_doaj_org_article_1ef1a1af9237404b8526eb674951b943
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_1ef1a1af9237404b8526eb674951b943
Other Identifiers
ISSN
2051-1426
E-ISSN
2051-1426
DOI
10.1136/jitc-2022-005463
