Dual regulatory switch through interactions of Tcf7l2/Tcf4 with stage-specific partners propels olig...
Dual regulatory switch through interactions of Tcf7l2/Tcf4 with stage-specific partners propels oligodendroglial maturation
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Author / Creator
Zhao, Chuntao , Deng, Yaqi , Liu, Lei , Yu, Kun , Zhang, Liguo , Wang, Haibo , He, Xuelian , Wang, Jincheng , Lu, Changqing , Wu, Laiman N , Weng, Qinjie , Mao, Meng , Li, Jianrong , van Es, Johan H , Xin, Mei , Parry, Lee , Goldman, Steven A , Clevers, Hans and Lu, Q. Richard
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Constitutive activation of Wnt/β-catenin inhibits oligodendrocyte myelination. Tcf7l2/Tcf4, a β-catenin transcriptional partner, is required for oligodendrocyte differentiation. How Tcf7l2 modifies β-catenin signalling and controls myelination remains elusive. Here we define a stage-specific Tcf7l2-regulated transcriptional circuitry in initiating...
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Full title
Dual regulatory switch through interactions of Tcf7l2/Tcf4 with stage-specific partners propels oligodendroglial maturation
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TN_cdi_doaj_primary_oai_doaj_org_article_1f0426bb84984cb2bac173cddf0948c3
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_1f0426bb84984cb2bac173cddf0948c3
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms10883
