Side chain to main chain hydrogen bonds stabilize a polyglutamine helix in a transcription factor
Side chain to main chain hydrogen bonds stabilize a polyglutamine helix in a transcription factor
About this item
Full title
Author / Creator
Escobedo, Albert , Topal, Busra , Kunze, Micha B. A. , Aranda, Juan , Chiesa, Giulio , Mungianu, Daniele , Bernardo-Seisdedos, Ganeko , Eftekharzadeh, Bahareh , Gairí, Margarida , Pierattelli, Roberta , Felli, Isabella C. , Diercks, Tammo , Millet, Oscar , García, Jesús , Orozco, Modesto , Crehuet, Ramon , Lindorff-Larsen, Kresten and Salvatella, Xavier
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Polyglutamine (polyQ) tracts are regions of low sequence complexity frequently found in transcription factors. Tract length often correlates with transcriptional activity and expansion beyond specific thresholds in certain human proteins is the cause of polyQ disorders. To study the structural basis of the association between tract length, transcri...
Alternative Titles
Full title
Side chain to main chain hydrogen bonds stabilize a polyglutamine helix in a transcription factor
Authors, Artists and Contributors
Author / Creator
Topal, Busra
Kunze, Micha B. A.
Aranda, Juan
Chiesa, Giulio
Mungianu, Daniele
Bernardo-Seisdedos, Ganeko
Eftekharzadeh, Bahareh
Gairí, Margarida
Pierattelli, Roberta
Felli, Isabella C.
Diercks, Tammo
Millet, Oscar
García, Jesús
Orozco, Modesto
Crehuet, Ramon
Lindorff-Larsen, Kresten
Salvatella, Xavier
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_1f190bc76aba4d9fb248940a644fa9a9
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_1f190bc76aba4d9fb248940a644fa9a9
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-09923-2
